Medicube AGE-R Ultra Tune 40.68 Review: Is the RF Upgrade Worth It?

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Prices last checked on September 27, 2026 and rounded to the dollar. Amazon prices change often; the price shown at checkout is the one that applies.

What Is 40.68MHz Radiofrequency?

Radiofrequency energy heats tissue by causing oscillation of water molecules and ions in the dermis — the same principle as a microwave oven, but at much lower power and with precise depth targeting. The frequency determines how deeply the energy penetrates:

**Lower frequencies (0.3–3MHz)**: Penetrate more deeply — used in surgical RF ablation and Thermage (6.78MHz) for deep SMAS-layer heating.

**Higher frequencies (30–50MHz)**: Shallower penetration, targeting the upper dermis at 1–2mm depth — the zone where fibroblasts responsible for collagen synthesis concentrate.

**40.68MHz** sits in one of the ISM bands, frequency windows set aside for industrial, scientific and medical RF use. Medicube doesn't publish a treatment depth or output power for the Ultra Tune, so how deep and how warm it heats at home settings isn't independently documented. Its Amazon listing describes six tips spaced 6mm apart in a hexagon, with waves forming a 3mm radius.

Ultra Tune 40.68 vs AGE-R Booster Pro: The Key Differences

| Feature | Booster Pro X2 | Ultra Tune 40.68 | |---|---|---| | Main technology | Electroporation-style Booster mode + microcurrent and other modes | 40.68MHz RF + microcurrent (Dual Tune-Wave) | | Radiofrequency | No | Yes, 40.68MHz | | Modes | 7 modes, 6 intensity levels | 2-in-1 elasticity and line care | | Gel | Used over a serum | No special gel; use after skincare absorbs | | App | Yes | Yes (AGE-R app) | | Price (Amazon) | About $200 | About $199 | | Best For | Serum absorption and glow | Elasticity and lines |

**The core difference**: The Booster Pro works with electrical pulses and low-level currents to help serums absorb and to tone. The Ultra Tune uses RF, which works by gently warming the skin, together with microcurrent. They're complementary rather than an upgrade path: one targets what you put on your skin, the other targets firmness.

Editor's Product Picks

Affiliate links — we earn a small commission at no extra cost to you.

40.68MHz RF + Microcurrent (Dual Tune-Wave), No Gel Needed

Medicube AGE-R Ultra Tune 40.68

~$199

Sold by Medicube & Aprilskin, a third-party sellerShop Now →

7 Modes: Booster, Microcurrent, Derma Shot, Air Shot | 6 Intensities

Medicube Booster Pro X2

~$200

Sold by Medicube & Aprilskin, a third-party sellerThe original Age-R Booster Pro is now sold on Amazon only in a low-stock set, so this is its successor, the Booster Pro X2.Shop Now →

Salmon DNA PDRN + Peptides, 30ml

Medicube PDRN Pink Peptide Serum

~$19

Sold by Medicube & Aprilskin, a third-party sellerMedicube doesn't sell a PDRN ampoule made for Age-R devices; this is its PDRN serum.Shop Now →

Prices last checked on September 27, 2026 and rounded to the dollar. Amazon prices change often; the price shown at checkout is the one that applies.

How 40.68MHz RF Stimulates Collagen

When RF energy heats dermal tissue to the therapeutic window (40–43°C), several sequential biological responses occur:

**Immediate**: Existing collagen fibres partially denature — triple-helix structures partially unwind, causing immediate tissue contraction and a transient tightening effect visible right after treatment.

**Short-term (2–4 weeks)**: Heat-shock proteins (HSP47, HSP70) are upregulated in fibroblasts. HSP47 is a collagen-specific chaperone — its upregulation directly increases collagen synthesis rate.

**Long-term (4–12 weeks)**: New collagen I deposits replace the partially denatured collagen III. Skin thickness measurably increases, elastin fibres reorganise, and sustained tightening develops progressively.

These responses are documented for professional RF treatments at therapeutic temperatures. Home devices run at lower power for safety, and Medicube doesn't publish the temperatures the Ultra Tune reaches, so expect a gentler, slower version of this effect.

How to Use It

Medicube's instructions for the Ultra Tune are simple:

1. Apply your usual skincare and let it absorb fully. No special gel is needed. 2. Place the device so all six tips touch the skin, then work across the face. 3. Use the AGE-R app for guide videos, a tracking calendar, progress photos and personalised settings.

**Frequency**: Medicube says it's fine to use every day.

If you also own the Booster Pro, use it for serum absorption as part of your routine, and use the Ultra Tune once your skincare has absorbed, as Medicube directs.

Results Timeline

**After a session**: A warm, glowy look is common, largely from increased circulation.

**Over several weeks**: Any change in firmness and fine lines builds gradually with regular use, if it comes at all. RF works on a slower timescale than serum-based results.

**Evidence**: Studies of professional RF devices show collagen changes over months. We couldn't find an independent study of the Ultra Tune itself, so treat any specific percentage or timeline claimed for home RF devices with caution.

Is the RF Upgrade Worth It?

**Yes, if your primary concern is firmness and lines.** RF is a different mechanism from electroporation, and the Ultra Tune is built around it. It's also easy to use: no special gel, and Medicube says daily use is fine.

**No, if your primary use case is helping serums absorb.** That's what the Booster Pro X2 does, and the Ultra Tune isn't designed for it.

**At the same price**: The Ultra Tune (about $199) and the Booster Pro X2 (about $200) cost about the same on Amazon, so choose by goal rather than by tier. Users 35+ focused on firmness, and anyone considering regular professional RF facials, are the Ultra Tune's natural audience.